发明名称 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME
摘要 The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and -(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula: -L-O-PAGR.R2]q where L is a optional linker moiety selected from the group consisting of -CH2O-, -CH2OX-, -OX-, -C(O)-, -C(O)X, -NH-, -NHC(O)-, -XNHC(O)-, -NHC(O)X-, -C(O)NH-, -C(O)NHX-, and where X is alky1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.
申请公布号 EP1651163(A4) 申请公布日期 2008.03.26
申请号 EP20040752108 申请日期 2004.05.06
申请人 BIOCON LIMITED 发明人 EKWURIBE, NNOCHIRI N.;ODENBAUGH, AMY L.
分类号 C07C43/20;A61K;C07C43/23;C07C45/67;C07C45/71;C07C47/575;C07C49/84;C07C235/48;C07C259/00;C07C271/00;C07C271/22;C07C271/28 主分类号 C07C43/20
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