BIOREACTOR SYSTEM AND METHOD OF ENHANCING FUNCTIONALITY OF MUSCLE CULTURED IN VITRO
摘要
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.
申请公布号
EP1902127(A2)
申请公布日期
2008.03.26
申请号
EP20060750099
申请日期
2006.04.13
申请人
WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人
YOO, JAMES;STITZEL, JOEL;ATALA, ANTHONY;CHRIST, GEORGE