Nanoparticle - i-motif nucleic acid bioconjugates

摘要

A bioconjugate comprising a nanoparticle bound to at least one nucleic acid adapted to form an i-motif structure. The assembly of the bioconjugates can be controlled by the pH value or temperature. The nanoparticle is preferably gold. The methods provide bioconjugates for colourimetric sensors, tumour diagnosis and therapy, drug delivery and nano-array deposition.