Cyclic amine compounds as CCR5 antagonists

摘要

A compound of formula (I) (wherein R¹ is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R² is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R¹ and R² may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N⁺-R⁵.Y^- (R⁵ is a hydrocarbon group; Y^- is a counter anion); R³ is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R⁴ is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G¹ is a bond, CO or SO₂; G² is CO, SO₂, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C_1-3 aliphatic hydrocarbon which may be substituted; provided that J is methine when G₂ is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G¹ is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).