发明名称 Method for preparing colloidal particles in the form of nanocapsules
摘要 The invention relates to a process for the preparation of dispersible colloidal systems in the form of nanocapsules whose wall consists of a polymer obtained by the polycondensation of two monomers, alpha and beta, and whose core consists of a substance B, characterized in that: (1) a first liquid phase is prepared which consists of a solution of monomer alpha in a solvent or solvent mixture and contains one or more surfactants and the substance B in solution or suspension; (2) a second liquid phase is prepared which consists of a non-solvent or non-solvent mixture for the monomer alpha and contains the monomer beta and one or more surfactants, the solvent or solvent mixture of the first phase being miscible in all proportions with the non-solvent or non-solvent mixture of the second phase; (3) the first phase is added to the second, with moderate agitation, to give a colloidal suspension of nanocapsules, agitation being maintained until the monomers alpha and beta have completely polymerized; and (4) if desired, all or part of the solvent or solvent mixture and non-solvent or non-solvent mixture is removed to give a colloidal suspension having the desired concentration of nanocapsules.
申请公布号 US7348031(B2) 申请公布日期 2008.03.25
申请号 US20020203656 申请日期 2002.10.18
申请人 UNIVERSITE CLAUDE BERNARD LYON I 发明人 MONTASSER IMED;FESSI HATEM;BRIANCON STEPHANIE;LIETO JOSEPH
分类号 A61K9/50;A61K9/51;A61K31/167;A61P25/20;B01J13/06;B01J13/14;B01J13/16 主分类号 A61K9/50
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