COMPOSITION FOR PREVENTING OR TREATING A NEURODEGENERATIVE DISEASE COMPRISING ACTIVE INGREDIENTS ISOLATED FROM THE STEMBARK OF VITIS VINIFERA, WHICH HAS INHIBITORY EFFECT ON BACE-1

摘要

A composition comprising an extract of stembark of Vitis vinifera is provided to inhibit BACE-1(beta-site APP-cleaving enzyme 1) mediating formation of beta-amyloid, known to be a causing material of various dementia such as Alzheimer's disease, thereby being usefully used for preventing and treating neurodegenerative diseases such as senile dementia. A pharmaceutical composition for preventing or treating neurodegenerative diseases comprises a compound selected from the group consisting of vitisin A, epsilon-viniferin, ampelopsin A and a mixture thereof as an effective ingredient, wherein the compound is obtained by extracting stembark of Vitis vinifera with an organic solvent selected from the group consisting of C1-4 alcohol and an aqueous solution thereof, dichloromethane, ethyl acetate and a mixture thereof.