发明名称 |
PRODRUGS VON ANTIVIRALEN MITTELN AUF BASIS VON PIPERAZIN UND SUBSTITUIERTEM PIPERIDIN |
摘要 |
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy. |
申请公布号 |
DE602005004517(D1) |
申请公布日期 |
2008.03.13 |
申请号 |
DE20056004517T |
申请日期 |
2005.03.03 |
申请人 |
BRISTOL-MYERS SQUIBB CO. |
发明人 |
UEDA, YASUTSUGU;CONNOLLY, TIMOTHY P.;KADOW, JOHN F.;MEANWELL, NICHOLAS A.;WANG, TAO;CHEN, CHUNG-PIN H.;YEUNG, KAP-SUN;ZHANG, ZHONGXING;LEAHY, DAVID KENNETH;PACK, SHAWN K.;SOUNDARARAJAN, NACHIMUTHU;SIRARD, PIERRE;LEVESQUE, KATHIA;THORAVAL, DOMINIQUE |
分类号 |
C07F9/09;A61K31/437;A61K31/496;A61K31/675;A61P31/18;C07D471/04;C07F9/572;C07F9/6561 |
主分类号 |
C07F9/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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