HIV INHIBITORS

摘要

The present invention provides a system for identifying HIV fusion inhibitors, and particularly for identifying small molecule inhibitors compounds that inhibit HIV fusion. The present invention further provides small molecule inhibitors of HIV fusion. In some embodiments, the invention provides small molecule inhibitors that bind to gp41. In some embodiments, inventive small molecule inhibitors block the gp41 conformational change associated with fusion. In some embodiments, inventive small molecule inhibitors inhibit binding of a peptide that corresponds to a portion of the gp41 outer layer with its site on the gp41 inner core.