<p>The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.</p>
申请公布号
WO2008030627(A2)
申请公布日期
2008.03.13
申请号
WO2007US19754
申请日期
2007.09.10
申请人
UNIVERSITY OF CINCINNATI;DORN, GERALD, W.;LIGGETT, STEPHEN, B.