COMPOUND HAVING INHIBITORY ACTIVITY ON HISTONE DEACETYLASE, AND PHARMACEUTICAL COMPRISING THE COMPOUND AS ACTIVE INGREDIENT

摘要

Disclosed is a novel compound having an inhibitory activity on histone deacetylase, which comprises a cyclic tetrapeptide derivative represented by the general formula (1). Also disclosed is a pharmaceutical comprising the compound as an active ingredient. (1) wherein the cyclic tetrapeptide moiety is a known structure; R<SUB>1</SUB> and R<SUB>2</SUB> independently represent an alkylene group which may have a branch having 1 to 6 carbon atoms; X represents a group selected from -CO-, -O-, -S- and -SO-; and Y represents a hydrogen, a halogen, a phenyl group (including a substituted form), a pyridyl group (including a substituted form), an alkyl group having 1 to 6 carbon atoms (including a halogen-substituted form, ditto with the groups described below), an alkyloxy group having 1 to 6 carbon atoms, an alkylcarbonyl group having 1 to 6 carbon atoms, an alkyloxycarbonyl group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, an alkylthiocarbonyl group having 1 to 6 carbon atoms or a mono- or di-alkylamino group having 1 to 6 carbon atoms, provided that, when Y represents a phenyl group (including a substituted form) or a pyridyl group (including a substituted form), Y may have a cyclic structure bound to R<SUB>2</SUB>.