ACTIVE SUBSTANCES, PHARMACEUTICAL COMPOSITION AND A METHOD FOR THE PRODUCTION AND USE THEREOF

摘要

The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances for producing medicinal preparations used for preventing and treating influenza and acute respiratory diseases. The substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, are proposed for the use thereof in the form of active substances of pharmaceutical compositions exhibiting antiviral activity against influenza and acute respiratory diseases, wherein R1, R14 and R24 independently of each other are an aminogroup substituent selected for hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, or R14 and R24 together with a nitrogen atom,with which they are bound, form through R14 and R24 optionally substituted azaheterocyclyl or guanidyl; R 2 is an alkyl substituent selected from hydrogen, an optionally substituted mercaptogroup, optionally substituted aminogroup and optionally substituted hydroxyl; R 3 is lower alkyl, R 5 is an hydrogen atom or R 5 together with an oxygen atom with which it is linked or R24 together with a nitrogen atom with which it is linked close, via R 5 and R24 an oxazine cycle; R 6 is a cyclic system substituent selected for hydrogen, a halogen atom, cyanogroup, optionally substituted aryl or substituted heterocyclyl.