NERVE FIBER DEGENERATION INHIBITOR

摘要

It was verified that by an experiment using a gene-silencing nucleic acid (GalNAcST siRNA), which is a substance having an "action of inhibiting the synthesis" of chondroitin sulfate proteoglycan (CSPG), chondroitinase ABC, which is a substance having an "action of promoting the degradation" of CSPG and C4-sulfatase, which is a substance having an "action of desulfating" CSPG, a substance that "inhibits the production or accumulation of CSPG" in a totally different route of a totally different property has an effect of inhibiting nerve fiber degeneration. It was revealed that the substance that "inhibits the production or accumulation of CSPG" which is a feature common to these is useful for inhibiting nerve fiber degeneration. The invention relates to a nerve fiber degeneration inhibitor containing a substance that inhibits the production or accumulation of CSPG as an active ingredient and a screening method for the nerve fiber degeneration inhibitor.