Modified hemoglobin with allosteric effector conjugated

摘要

The present invention relates generally to a modified hemoglobin with an allosteric effector conjugated which is capable of dynamically regulating the efficiency of oxygen release. The hemoglobin composition provided in the present invention is utilizing maleimide-Polyethylene glycol-N-hydroxysuccinimidyl as a linker to crossbridge the peptide comprising SEQ ID NO: 1 to the surface of a hemoglobin, and hence, it would able to modulate the oxygen affinity through the characteristic of the peptide which could enter into the central cavity formed between beta-<img id="CUSTOM-CHARACTER-00001" he="2.79mm" wi="1.78mm" file="US20080064855A1-20080313-P00001.TIF" img-content="character" img-format="tif"/> chains of hemoglobin under an appropriate oxygen concentration.