发明名称 |
NOVEL BIOCONJUGATES AS THERAPEUTIC AGENT AND SYNTHESIS THEREOF |
摘要 |
The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG peptide motif and biomolecules such as aminosugars, hydroxyamino acids, hydroxyamino acid esters, aminolipids, polyamines; nucleic acids or derivatives thereof; or any molecule having such moieties; or any compound having such moieties to obtain a bioconjugates useful for target delivery of a compound. The present disclosure provides bioconjugates obtained by the novel sortase catalysed transpeptidedation reaction. |
申请公布号 |
WO2007108013(A3) |
申请公布日期 |
2008.03.13 |
申请号 |
WO2007IN00115 |
申请日期 |
2007.03.21 |
申请人 |
NATIONAL INSTITUTE OF IMMUNOLOGY;ROY, RAJENDRA, PRASAD;SAMANTARAY, SHARMISHTHA |
发明人 |
ROY, RAJENDRA, PRASAD;SAMANTARAY, SHARMISHTHA |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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