OCULAR FIBROUS NEOVASCULARIZATION INHIBITOR

摘要

The invention relates to a chorioretinal neovascularization inhibitor suitable for treating or preventing chorioretinal neovascularization diseases, such as versican siRNA containing a core site sequence of versican, which is one of the chondroitin sulfate proteoglycans, or chondroitin-4-desulfatase which desulfating the sulfate group at the 4-position of chondroitin sulfate proteoglycan as an example of examining an effect of accumulation of chondroitin sulfate proteoglycan (CSPG). The invention also relates to a method of inhibiting chorioretinal neovascularization based on the inhibition of accumulation of chondroitin sulfate proteoglycan (CSPG) by administering versican siRNA, chondroitin-4-desulfatase or the like to a subject, and a method of treating or preventing chorioretinal neovascularization diseases such as diabetic retinopathy utilizing the same.