MEANS AND METHODS FOR THE PRODUCTION OF AMYLOID OLIGOMERS

摘要

The present invention relates to the field of amyloid disorders, more par ticularly to the field of diseases where protein misfolding leads to the gen eration of insoluble amyloid fibers in tissues and organs. The invention pro vides methods for the production of soluble, toxic amyloid oligomers. The in vention further provides assays using said amyloid oligomers to screen for m olecules that interfere with the toxicity of said oligomers.