发明名称 |
D-AMINO ACID DEHYDROGENASE AND METHOD OF MAKING D-AMINO ACIDS |
摘要 |
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of, e.g., a diaminopimelate dehydrogenase. Also provided is a method of making a D-amino acid using a catalytically active polypeptide, wherein a 2-ketoacid is allowed to contact the polypeptide in the presence of a nicotinamide cofactor and ammonia or an ammonia source. |
申请公布号 |
EP1896574(A2) |
申请公布日期 |
2008.03.12 |
申请号 |
EP20060748972 |
申请日期 |
2006.03.28 |
申请人 |
BIOCATALYTICS INC. |
发明人 |
NOVICK, SCOTT, J.;ROZZELL, DAVID, J. |
分类号 |
C12N9/06;C12N15/11;C12N15/52;C12P13/04 |
主分类号 |
C12N9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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