| 发明名称 |
A DIRECT DRUG DELIVERY SYSTEM BASED ON THERMALLY RESPONSIVE BIOPOLYMERS |
| 摘要 |
<p>A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.</p> |
| 申请公布号 |
EP1896072(A2) |
申请公布日期 |
2008.03.12 |
| 申请号 |
EP20060785402 |
申请日期 |
2006.06.21 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
SETTON, LORI A.;CHILKOTI, ASHUTOSH;KRAUS, VIRGINIA B.;BETRE, HELAWE;DREHER, MATTHEW R. |
| 分类号 |
A61K47/48;A61K38/07;A61K38/08;A61K38/20;A61K38/39;A61K39/395;A61K39/44;A61M31/00;A61P19/02;A61P29/00 |
主分类号 |
A61K47/48 |
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