发明名称 |
MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION |
摘要 |
The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; R<l> is Ar<1> or a monocyclic or bicyclic heterocycle Q is R<7>, pyrrolidinyl substituted with R<7>, piperidinyl substituted with R<7> or homopiperidinyl substituted with R<7>; one of R<2a >and R<3a >is selected from halo, optionally mono- or polysubstituted Cl-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar<2>, N(R<4a>R<4>), N(R<4a>R<4>)sulfonyl, N(R<4a>R<4b>)carbonyl, C1-6alkyloxy, Ar<2>oxy, Ar<2>Cl-6alkyloxy, carboxyl, Cl-6alkyloxycarbonyl, or -C(=Z)Ar<2>; and the other one of R<2a >and R<3a> is hydrogen; in case R<2a >is different from hydrogen then R<2b >is hydrogen, C1-6alkyl or halogen and R<3b >is hydrogen; in case R<3a >is different from hydrogen then R<3b> is hydrogen, C1-6alkyl or halogen and R<2b >is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine. |
申请公布号 |
EP1697345(B1) |
申请公布日期 |
2008.03.12 |
申请号 |
EP20040817576 |
申请日期 |
2004.12.20 |
申请人 |
TIBOTEC PHARMACEUTICALS LTD. |
发明人 |
BONFANTI, JEAN-FRANCOIS;ANDRIES, KOENRAAD, JOZEF, LODEWIJK;FORTIN, JEROME, MICHEL, CLAUDE;MULLER, PHILIPPE;DOUBLET, FREDERIC, MARC, MAURICE;MEYER, CHRISTOPHE;WILLEBRORDS, RUDY, EDMOND;GEVERS, TOM, VALERIUS, JOSEPHA;TIMMERMAN, PHILIP, MARIA, MARTHA, BERN |
分类号 |
C07D401/06;A61K31/4184;A61P11/00;A61P31/12;C07D401/14;C07D413/14 |
主分类号 |
C07D401/06 |
代理机构 |
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