PONCIRUS POLYANDRA EXTRACTS HAVING WHITENING ACTIVITY AND ANTI-INFLAMMATORY ACTIVITY

摘要

An extract of Poncirus polyandra is provided to whiten the skin by inhibiting activity of melanocyte and tyrosinase, inhibit oxidation by removing DPPH(1.1-diphenyl-2-picrylhydrazyl) radical and suppress inflammation without side effects, so that the extract is useful for skin whitening, and prevention and treatment of inflammatory disease. An extract of Poncirus polyandra having skin-whitening, anti-oxidative and anti-inflammatory effects is prepared by washing immature Poncirus polyandra with water, pulverizing the washed Poncirus polyandra, freeze-drying the pulverized Poncirus polyandra, dipping the pulverized product in 70% ethanol with agitation at room temperature for 2-3 days, filtering the extract of Poncirus polyandra, concentrating the filtered extract of Poncirus polyandra under reduced pressure, suspending the concentrates in distilled water, and extracting the suspension with hexane, ethylacetate and butanol sequentially. A composition for whitening the skin or preventing and treating inflammatory disease comprises the extract of Poncirus polyandra.