Methods and uses of leukotriene B4 hydroxylases to treat diseases

摘要

Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B₄ (LTB₄) in those in need of such treatment using LTB₄ hydroxylases. In certain embodiments, LTB₄ hydroxylase is administered in combination with nicotinamide adenine dinucleotide phosphate and/or an NADPH-cytochrome P-450 reductase. The invention is particularly useful for treating or preventing respiratory diseases that are caused or exacerbated by inflammation.