发明名称 |
METHOD FOR THE PREPARATION OF POLYMERIC MICELLE VIA PHASE SEPARATION OF BLOCK COPOLYMER |
摘要 |
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium comprising mixing an effective amount of a hydrophobic drug, an amphiphilic block copolymer and a phase separation medium comprising liquid poly(ethylene glycol), stirring an d heating to give a solution; cooling and stirring the solution until it forms a polymeric micelle by phase separation; diluting the polymeric micelle soluti on in distilled water and then dialyzing it against excess water to remove the liquid polyethylene glycol; and freeze-drying the dialyzed aqueous solution to give a polymeric micellar composition in a powdered state.
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申请公布号 |
CA2408548(C) |
申请公布日期 |
2008.03.11 |
申请号 |
CA20012408548 |
申请日期 |
2001.05.11 |
申请人 |
SAMYANG CORPORATION |
发明人 |
YU, JAE WON;SEO, MIN HYO;YI, YIL WOONG |
分类号 |
A61K47/30;A61K47/34;A61K9/107;A61K9/14;A61K9/19;A61K9/51;A61K31/337;A61K31/4745;A61K31/5575;A61K31/568;A61K31/704;A61K33/24;A61K38/00;B01J13/06;B01J13/20 |
主分类号 |
A61K47/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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