发明名称 |
Peptidomimetic inhibitors of STAT activity and uses thereof |
摘要 |
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include compounds of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.
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申请公布号 |
US7342095(B2) |
申请公布日期 |
2008.03.11 |
申请号 |
US20040784309 |
申请日期 |
2004.02.20 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
TURKSON JAMES;JOVE RICHARD;SEBTI SAID M.;HAMILTON ANDREW D. |
分类号 |
A61K38/06;A61K38/00;A61K38/04;A61K38/16;A61P35/00;C07K5/04;C07K5/06;C07K5/08;C07K7/06 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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