Medical use for tachykinin antagonists

摘要

The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. wherein R represents the ring A or 2-pyridinyl or 2-pyridinyl-N-oxide; R¹ is selected from halogen atoms and C_1-4alkyl, C_1-4alkoxy, trifluoromethyl, and S(O)_nC_1-4alkyl groups; R² and R³, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C_1-4alkyl, C_1-4alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.