| 摘要 |
<p>Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(-)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(-)-binol, and removing the (S)-(-)-binol moiety from the crystallized inclusion complex.</p> |
