发明名称 |
CARRIER FOR TARGETING NERVE CELLS. |
摘要 |
<p>The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by <i>Clostridium botulinum</i> wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.</p> |
申请公布号 |
MX2007013284(A) |
申请公布日期 |
2008.03.07 |
申请号 |
MX20070013284 |
申请日期 |
2006.04.26 |
申请人 |
TOXOGEN GMBH |
发明人 |
TANJA WEIL;ANDREAS RUMMEL;ALEKSANDRS GUTCAITS |
分类号 |
C07K14/195;A61K38/00;C07K14/33 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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