INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2

摘要

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAE). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein. ® KIPO & WIPO 2008