AN EFFICIENT PROCESS FOR THE PREPARATION OF D-ERYTHRO-SPHINGOSINE

摘要

A method for preparing D-erythro-sphingosine of a natural substance is provided to obtain a sphingosine having trans selectivity and to lower a manufacturing cost by using D-ribo-phytosphingosine. A method for preparing D-erythro-sphingosine comprises the steps of reacting a compound represented by the formula 4 with SOx and oxidizing it, or reacting a compound represented by the formula 4 with SO2X2, thereby preparing a compound represented by the formula 5; cyclic ring opening the compound represented by the formula 5; deprotecting the P2O group of the obtained compound to prepare a compound represented by the formula 3; and deprotecting the compound of the formula 3 to obtain the D-erythro-sphingosine represented by the formula 1, wherein X is a halogen atom; P1 is NH3 or N4; and P2 and P3 are a protecting group.