METHOD OF MODULATION OF EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INVOLVING MIRNA
摘要
<p>The present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) and its downstream signalling effectors. In particular, the present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) or like molecule in a cell comprising contacting said cell with an agent capable of directly or indirectly interacting with the 3 ' -untranslated region (UTR) of the mRNA of said EGFR or like molecule, wherein the UTR is encoded by a sequence which comprises a sequence having at least about 70% identity with at least one sequence selected from the group consisting of the sequences set forth in SEQ ID NOs: 1-36.</p>
申请公布号
WO2008025073(A1)
申请公布日期
2008.03.06
申请号
WO2007AU01247
申请日期
2007.08.28
申请人
THE UNIVERSITY OF WESTERN AUSTRALIA;LEEDMAN, PETER;GILES, KEITH;WEBSTER, REBECCA, JANE
发明人
LEEDMAN, PETER;GILES, KEITH;WEBSTER, REBECCA, JANE