摘要 |
Novel compositions derived from antigen-binding sites of immunoglobulins having affinity for IL-31 are provided. The compositions exhibit immunologic al binding properties of antibody molecules capable of binding specifically to a human IL-31. CDR regions derived from same or different immunoglobulin moieties are provided. Also provided are single chain polypeptides wherein V H and VL domains are attached. The sFv molecules can include ancillary polyp eptide moieties which can be bioactive, or which provide a site of attachmen t for other useful moieties. The compositions are useful in specific binding assays, affinity purification schemes, drug or toxin targeting, imaging, an d genetic or immunological therapeutics for inflammatory diseases. The inven tion thus provides novel polypeptides, the DNAs encoding those polypeptides, expression cassettes comprising those DNAs, and methods of inducing the pro duction of the polypeptides. The invention further provides the amino acid s equences of the variable regions of the monoclonal antibodies and use of the se monoclonal antibody or antibody fragment in conjunction with an an human IgG4 Fc molecule.
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