CHARGE-MODIFIED LYSOZYME ANTIMICROBIAL COMPOSITIONS, SURFACTANTS, AND METHODS FOR INFECTIONS AND CYSTIC FIBROSIS

摘要

The invention comprises charge modified antimicrobials, including charge modified lysozymes, as well as compositions and methods for potentiating antimicrobial activity by modifying a net charge level of the antimicrobial. Also provided is a method of treating microbial infections, including infections associated with cystic fibrosis, comprising administering or co-administering a compound of the invention. The invention provides compositions and methods of potentiating antibiotic treatment by administration of an at least partially cationic or positively-charged surfactant composition. Cationic lipid compositions including DOTAP:DOPE formulations are disclosed.