发明名称 SPIRO ANTIBIOTIC DERIVATIVES
摘要 The invention relates to compounds of formula (I) wherein R1 represents H , alkyl, alkoxy, cyano or halogen; one of U and X represents CH or N and the other represents CH, or, in the case of U, may also represent CRa and, in t he case of X, may also represent CRb; Ra represents halogen; Rb represents h alogen or alkoxy; B represents N, D represents CH2 and A represents CH(OH)CH 2 or CH2CH2, or B represents CH, D represents CH2 or O and A represents OCH2 , CH2CH(OH), CH(OH)CH2, CH(OH)CH(OH), CH=CH, CH2CH2 Or NHCO, or also B repre sents C(OH), D represents CH2 and A represents OCH2, CH2CH(OH), CH(OH)CH2, C H(OH)CH(OH), CH=CH, CH2CH2 Or NHCO; R2 represents H, alkyl, alkenyl, hydroxy alkyl or alkoxycarbonylalkyl; and E represents naphthyl or a binuclear heter ocyclic group; and to salts of such compounds. These compounds are useful as antimicrobial agents.
申请公布号 CA2659493(A1) 申请公布日期 2008.03.06
申请号 CA20072659493 申请日期 2007.08.29
申请人 ACTELION PHARMACEUTICALS LTD 发明人 SURIVET, JEAN-PHILIPPE;ZUMBRUNN-ACKLIN, CORNELIA;HUBSCHWERLEN, CHRISTIAN
分类号 C07D498/10;A61K31/424;A61P31/04 主分类号 C07D498/10
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