| 摘要 |
The present invention provides nonamer peptides derived from fibroblast activation protein alpha (FAPalpha) for the treatment of solid tumors. These peptides specifically bind to HLA, defined by an IC<SUB>50 </SUB>value of less than about 50 muM, induce a T cell response in a subject, wherein position No. 2 of said nonamer peptide is leucine (L), isoleucine (I) or methionine (M), and position No. 9 of said nonamer peptide is leucine (L), valine (V) or isoleucine (I). Further, a composition comprising a nonamer peptide and methods for the prophylactic and therapeutic treatment are provided.
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