PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING BENZAZOLE DERIVATIVES AS AN ACTIVE INGREDIENT

摘要

A novel benzazole derivative is provided to control lipid metabolism and energy metabolism effectively by inhibiting the activity of diacylglycerol acyltransferase(DGAT) inducing metabolic disorder such as obesity and diabetes, thereby being usefully used for treating the metabolic disorder. A pharmaceutical composition for preventing and treating metabolic disorder such as obesity, diabetes, type 2 diabetes, hyperlipidemia and arteriosclerosis comprises a benzazole derivative represented by the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient. In the formula(1), R1 is a substituent at a C5 or C6 position of benzoxazole or benzimidazole and is selected from the group consisting of COORa, CONRbRc and SO2NH2(wherein Ra is H or C1-2 alkyl; each Rb and Rc is independently selected from the group consisting of C1-5 alkyl(which may be substituted by at least one substituent selected from the group consisting of C3-5 heteroaryl including at least one selected from the group consisting of N, O, and S, C3-5 heterocycle including at least one selected from the group consisting of N, O, and S, and amino substituted by C1-3 alkyl), H, amino and C1-3 alkyl; R2 is C1-10 alkyl, halogen or nitro; R3 is H or halogen; and X is O or NH).