发明名称 |
Drug delivery systems comprising solid solutions of weakly basic drugs |
摘要 |
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 mug/mL at pH 6.8. |
申请公布号 |
AU2007289235(A1) |
申请公布日期 |
2008.03.06 |
申请号 |
AU20070289235 |
申请日期 |
2007.08.29 |
申请人 |
EURAND, INC. |
发明人 |
LUIGI BOLTRI;FLAVIO FLABIANI;ITALO COLOMBO;LUIGI MAPELLI;GOPI VENKATESH;JIN-WANG LAI |
分类号 |
A61K9/14;A61K9/22;A61K31/4406;A61K31/4422;A61K31/454;A61K31/5513;A61K47/30;A61K47/38 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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