发明名称 |
Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof |
摘要 |
Provided are compounds which can be used in combination for treating diseases associated with a condition associated with cerebral accumulation of Alzheimer's amyloid, such as Alzheimer's disease. Also provided are methods of treating or reducing the risk of developing beta-amyloid production, beta-amyloid deposition, beta-amyloid neurotoxicity (including abnormal hyperphosphorylation of tau) and microgliosis associated with cerebral accumulation of Alzheimer's amyloid by administering therapeutically effective amounts of compounds which in combination can decrease beta-amyloid production and capacitative calcium entry in cells. Further provided are methods for diagnosing diseases associated with cerebral accumulation of Alzheimer's amyloid in animals or humans by administering diagnostically effective amounts of the compounds.
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申请公布号 |
US2008058330(A1) |
申请公布日期 |
2008.03.06 |
申请号 |
US20070774357 |
申请日期 |
2007.07.06 |
申请人 |
ROSKAMP RESEARCH LLC |
发明人 |
PARIS DANIEL;MULLAN MICHAEL J.;BAKSHI PANCHAM |
分类号 |
A61K31/4422;A61K31/122;A61K31/277;A61K31/343;A61K31/36;A61K31/381;A61K31/404;A61K31/4164;A61K31/4412;A61K31/4418;A61K31/443;A61K31/4439;A61K31/451;A61K31/4745;A61K31/517;A61P25/28;C12N5/00 |
主分类号 |
A61K31/4422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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