SUBSTITUTED PYRROLO[4,3-B]INDOLES, COMBINATORIAL AND FOCUSED LIBRARIES, PHARMACOLOGICAL COMPOSITION AND A METHOD FOR THE PRODUCTION AND USE THEREOF

摘要

The invention relates to synthesising novel chemical agents, to searching novel physiologically active substances, leading compounds, "molecular tools" and drug candidates produced by screening combinatorial and focused libraries of compounds, to a pharmaceutical composition and to methods for the production and use thereof. The invention claims hydrated pyrrolo[4,3-b]indoles of general formula 1, the racemates, optical and geometrical isomers and the pharmaceutically acceptable salts and/or hydrates thereof, wherein a dotted line with an unbroken line associated therewith (__----) is a single or double bond; R<SUP>1</SUP> and R<SUP>2</SUP> independently of one another represent aminogroup substituents, selected from hydrogen, of possibly substituted C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, possibly substituted by aryl, by hydrogen-containing heteroaryl; from C<SUB>1</SUB>-C<SUB>6</SUB> alkoxycarbonyl, possibly substituted phenyl, possibly carbonylamino or tiocarbonylamino substituted, substituted acyl, possibly substituted arylsulphonyl; R <SUP>i</SUP> <SUB>n</SUB>