LITSEA JAPONICA EXTRACTS HAVING ANTI-INFLAMMATORY ACTIVITY AND BONE METABOLISM FACTOR INHIBITION ACTIVITY

摘要

A composition comprising the extract of Litsea japonica is provided to prevent and treat inflammatory disease and metabolic bone disease including osteoporosis and osteopetrosis by inhibiting inflammation and bone metabolic factors including IL-6(interleukin-6), COX-2(cyclooxygenase-2) and PGE2(prostaglandin E2) without side effects. A composition for preventing and treating inflammatory disease and metabolic bone disease comprises the extract of Litsea japonica which is prepared by drying leaf, stem or fruit of Litsea japonica juss in the shade, pulverizing the dried Litsea japonica juss, dipping the pulverized Litsea japonica juss in 80% ethanol, sonicating the Litsea japonica juss solution for 1 hour, repeating the sonication in three times to prepare the ethanol extract of Litsea japonica juss, collecting the supernatant and concentrating the supernatant under reduced pressure, suspending the concentrate in distilled water, and extracting the suspension with hexane, dichloromethane, ethyl acetate and butanol sequentially, and is formulated as food additives or drink.