METHOD FOR EVALUATING COMPOUND USING PKC-iota

摘要

It is intended to find a target gene for an antitumor agent effective specifically in a cancer cell caused by abnormality of p53 or PI3 kinase, and to realize the evaluation of a compound using the gene. A method for evaluating a compound effective in the treatment of cancer characterized by comprising the steps of: preparing a cell expressing PKC-iota by introducing a PKC-iota gene; bringing a test compound into contact with the cell; and detecting a specific binding of the test compound to the PKC-iota. A method for evaluating a compound having the step of measuring the activity or expression level of an intracellular signal transducer induced by the contact instead of the detection step.