发明名称 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS |
摘要 |
Embodiments of methods of using siRNAs targeting VEGF including an siRNA defined by SEQ ID NO: 77 and SEQ ID NO: 78 to stabilize visual acuity in a subject, to inhibit choroidal neovascularization lesions, to treat age-related macular degeneration, to treat diabetic macular edema, and to decrease foveal thickness in subjects are disclosed. Additionally, methods of treating age-related macular degeneration and diabetic macular edema by administering combinatorial therapy comprising an siRNA targeting VEGF and a non-siRNA VEGF antagonist are described. |
申请公布号 |
WO2007146953(A3) |
申请公布日期 |
2008.03.06 |
申请号 |
WO2007US71029 |
申请日期 |
2007.06.12 |
申请人 |
EXEGENICS, INC., D/B/A OPKO HEALTH, INC.;REICH, SAMUEL, JOTHAM |
发明人 |
REICH, SAMUEL, JOTHAM |
分类号 |
A61K31/7105;A61K31/713;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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