PROCESSES FOR THE PURIFICATION OF (3R,4S)-4-(4-HYDROXY-PROTECTED-PHENYL)-1-(4-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-3-OXOPROPYL] AZETIDIN-2-ONE

摘要

Provided are processes for purifying (3R,4S)-4-(4-hydroxyprotected-phenyl)- l-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one having the following formula II, wherein X and Y are hydrogen or a substituted or unsubstituted C_1-8 alkyl; n is an integer between 0 and 3; and P is a hydroxyl protecting group. The Compound of formula II may be converted to an azetidinone compound, which is useful, for example, in reducing cholesterol in mammals.