PYRIMIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS

摘要

The present invention relates to compounds of Formula (1a) and pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers and N-oxides thereof, wherein W<SUP>1</SUP> and W<SUP>3</SUP> are N and W and W<SUP>4</SUP> are CR<SUP>12</SUP>, or W<SUP>1</SUP> and W<SUP>3</SUP> are CR<SUP>12</SUP> and W<SUP>2</SUP> and W<SUP>4</SUP> are N. The invention also relates to pharmaceutical compositions comprising these compounds, and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein-coupled receptor GPR119, such as diabetes and obesity.