| 摘要 |
A method for enhancing solubility of allantoin in a non-aqueous pharmaceutically acceptable alcohol carrier using a solubilization enhancer is described. Non-aqueous compositions containing the solubilized allantoin at the FDA-approved levels of 0.5% to 2% by weight are able to be obtained by using urea or urea derivatives as the solubilization enhancer. The non-aqueous topical composition is suitable for cosmetic, dermatological, and pharmaceutical use.
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