发明名称 |
SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES |
摘要 |
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent. |
申请公布号 |
EP1626050(A4) |
申请公布日期 |
2008.03.05 |
申请号 |
EP20040730460 |
申请日期 |
2004.04.30 |
申请人 |
EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;DALIAN UNIVERSITY OF TECHNOLOGY |
发明人 |
QIAN, XUHONG;LI, YONGGANG;XU, YUFANG;DING, JIAN;LIN, LIPING;MIAO, ZEHONG;ZHU, HONG;QU, BAOYUAN |
分类号 |
C07D495/06;A61K31/473;A61K31/4743;A61K31/4745;A61P35/00;C07D221/06;C07D221/14;C07D405/12;C07D513/06 |
主分类号 |
C07D495/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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