摘要 |
A method is provided for treating disorders of gastrointestinal motility which include the steps of administering to a patient in need of treatment of a compound having the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomers thereof, wherein R<SUB>1 </SUB>is selected from alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; Z is selected from -CON(R<SUB>4</SUB>)R<SUB>4a</SUB>, -SO<SUB>2</SUB>N(R<SUB>4</SUB>)R<SUB>4a</SUB>, -CN, and R<SUB>4 </SUB>and R<SUB>4a </SUB>are the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl or R<SUB>4 </SUB>and R<SUB>4a </SUB>can be joined together to form a heterocycle; R<SUB>4b </SUB>is selected from hydrogen, halogen, hydroxyl, CN, OCF<SUB>3</SUB>, CF<SUB>3</SUB>, CONH<SUB>2</SUB>, SONH<SUB>2</SUB>, SO<SUB>2</SUB>CH<SUB>3</SUB>, NHCOCH<SUB>3 </SUB>or NHCO<SUB>2</SUB>CH<SUB>3</SUB>; and Q is a substituted bicyclic heterocycle. New compounds for use in treating disorders of gastrointestinal motility are also provided.
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