发明名称 |
SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY |
摘要 |
Compounds of the general formula (I):wherein Ar<1 >represents optionally substituted aryl or heteroaryl;n represents 0 or 1;T, U, V, and W each independently represent nitrogen atom or optionally substituted methine group, where at least two of them represent the said methine group;X represents methine or hydroxy substituted methine;Y represents an optionally substituted imino or oxygen atom are described and claimed. These novel spiro compounds are useful as neuropeptide Y receptor antagonists and as agents for the treatment of various kinds of cardiovascular disorders, central nervous system disorders, metabolic diseases and the like. |
申请公布号 |
EP1483266(B1) |
申请公布日期 |
2008.02.27 |
申请号 |
EP20030710252 |
申请日期 |
2003.03.05 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
FUKAMI, TAKEHIRO;KANATANI, AKIO;ISHIHARA, AKANE;ISHII, YASUYUKI;TAKAHASHI, TOSHIYUKI;HAGA, YUJI;SAKAMOTO, TOSHIHIRO;ITOH, TAKAHIRO;CHIBA, MASATO |
分类号 |
C07D491/10;C07D491/107;A61K31/438;A61P1/00;A61P3/04;A61P3/06;A61P3/10;A61P5/00;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P13/12;A61P15/00;A61P25/00;A61P25/04;A61P25/08;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P27/06;A61P29/00;A61P43/00;C07D213/61;C07D307/94;C07D405/12;C07D471/10;C07D519/00 |
主分类号 |
C07D491/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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