Use of Vitamin D3 agonist in a mammalian model for atopic diseases and of Vitamin D3 antagonists for the treatment of atopic diseases

摘要

The present invention concerns a method for generating a human atopic disease-like phenotype, preferably an atopic dermatitis (AD)-like phenotype in a mammal comprising administrating to said mammal at least one compound selected in the group comprising the physiologically active vitamin D3 (1±,25 (OH) 2 D 3 ) and agonistic analogs thereof. The present invention also concerns a method for treating and/or preventing an atopic disease in a patient comprising administrating to said patient an effective amount of at least one vitamin D3 antagonist.