| 摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of 2-(azol-1-yl)ethaneamines that are used as the parent compounds in preparing biologically active compounds of medicinal and agriculture designation. Method for synthesis of 2-(azol-1-yl)ethaneamines of the general formula (I): wherein R1 means hydrogen atom or alkyl group comprising from 1 to 6 carbon atoms; each Z and X means independently -CH or nitrogen atom (N); or Z and X mean in common group -C-CH=CH-CH=CH-C that forms a system anellated with azole cycle involves the alkylation reaction of azole compounds wherein R1, Z and Y have the same values as in the formula (I) with oxazolines of the formula (II): wherein R2 means alkyl group comprising from 1 to 6 carbon atoms, phenyl, halogenphenyl group in the presence of Lewis acid or protonic acid to yield N-[2-(azol-1-yl)ethyl]alkaneamides of the formula (III): wherein R1, R2, Z and X have above given values followed by their hydrolysis in the presence of acids or bases in polar solvent medium at temperature 60-120C. ^ EFFECT: improved method of synthesis. ^ 5 cl, 17 ex |
