| 摘要 |
Compounds (I), compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases.
formula I:
wherein:
Y is COOH, COOR 5 , CONR 7 R 8 , tetrazolyl, CONHOH, B(OH) 2 , CONHSO 2 Ar, CONHCH(R 6 )COOH, OH, CH 2 OH or -(CH 2 ) n -C(R 6 )(NH 2 )-COOH;
X is O;
Het is heteroaryl, optionally substituted with halo, OR, alkyl or haloalkyl;
Ar, R, R 5 - R 8 and n are as described herein. |
