СПОСОБ РЕГИСТРАЦИИ СПЕЦИФИЧЕСКИХ МАКРОМОЛЕКУЛ В БИОЛОГИЧЕСКОЙ ПРОБЕ И УСТРОЙСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ

摘要

FIELD: medicine. ^ SUBSTANCE: claimed is method of registration of specific macromolecules in biological sample using combination of two methods: scanning probe microscopy and mass-spectrometry, which allows carrying out registration of macromolecules in analyte solution by method of atom-force microscopy and simultaneously identify caught molecules by means of mass-spectrometry methods. Method allows identifying macromolecules with sensitivity up to 10-19 M in process of carrying out proteomic, virusological, diagnostic research. ^ EFFECT: increase of method sensitivity. ^ 3 cl, 3 dwg